We’ll Drink to That: 15 Mezcal Cocktails for Cinco de Mayo

At OpenTable, we’ve got the right restaurants for you — especially on Cinco de Mayo. Many of the more than 51,000 restaurants around the world are prepping to party on Sunday, May 5. Bartenders are mixing up mezcal-centric libations to help ensure the fiestas go all day and well into the night. Take your Cinco de Mayo to the next level with mezcal cocktails and toast to Mexican culture and heritage. Not near any of these spots? Find a place near you on OpenTable.com.

Zuma, Miami, Florida
When your cocktail arrives in a skull, you know it’s not for the faint of heart. In fact, guests are limited to enjoying only two a night due to their high alcohol content. The Mexican Zombie features a heady mix of mezcal, overproof tequilas, velvet falernum, and absinthe. Make a reservation at Zuma.

Mezcal Cocktails for Cinco de Mayo

Trademark, New York, New York
You can’t not love a cocktail called the Hibisco Disco. It’s a party in your mouth! Featuring Ilegal mezcal, the Daiquiri-like drink is rounded out with cherry hibiscus syrup and orange blossom water. Make a reservation at Trademark.

Mezcal Cocktails for Cinco de Mayo

Doi Moi, Washington, D.C.
The cocktail is called Suffering Is Optional, but enjoying it is mandatory. It’s forged from Sombra mezcal, guava, papaya, Aperol, and lemon. Chili salt on the rim adds a flash of fire. Make a reservation at Doi Moi.

Mezcal Cocktails for Cinco de Mayo

Precinct Kitchen + Bar, Boston, Massachusetts
We pine for this tropical tipple. Casamigos mezcal adds another layer of smoky sensibility to the charred pineapple margarita. We won’t judge you if you order more than one. Make a reservation at Precinct Kitchen + Bar.

Mezcal Cocktails for Cinco de Mayo

Outlier, Seattle, Washington
You’re going to flip for this buzzy bev. Mezcal powers the Smoking Monk Flip, which boasts a complex flavor profile thanks to the incorporation of coffee syrup, green chartreuse, and mole bitters. Yes, it’s acceptable to drink one at breakfast. Make a reservation at Outlier.

Mezcal Cocktails for Cinco de Mayo

Waterbar, San Francisco, California
Two is better than one. Del Maguey Vida mezcal and Cazadores tequila reposado intertwine in the Pájaro Picante. Campari and grapefruit juice brighten it up and give it an edge. Make a reservation at Waterbar.

Mezcal Cocktails for Cinco de Mayo

Bertrand at Mister A’s, San Diego, California
Avocado toast, now in cocktail form. Del Maguey Vida is mixed with whipped avocado, tequila, Licor 43, and lime. Avo lovers are practically required to like (and Instagram) it. Make a reservation at Bertrand at Mister A’s.

Mezcal Cocktails for Cinco de Mayo

8UP, Louisville, Kentucky
The city’s only rooftop venue gives Cinco de Mayo partygoers the chance to live it up eight stories high while looking out over the stunning skyline. The Nada Problem is the perfect potable for the evening, featuring mezcal, pineapple, honey, and lime. It boasts a spicy whiplash thanks to some Tabasco hiding in its sunset-hued depths. Make a reservation at 8UP.

Mezcal Cocktails for Cinco de Mayo

Bakan, Miami, Florida
Spicy heat meets sugary sweet. The Sera Melon, Sera Sandia features mezcal, triple sec, lime juice, and watermelon syrup. It’s garnished with a watermelon slice so you can snack while you sip. Make a reservation at Bakan.

Mezcal Cocktails for Cinco de Mayo

Double Take, Los Angeles, California
The Bartender Always Lives is a liquid homage to Robert Rodriquez’s Desperado. Del Maguey Vida mezcal dances with jalapeño-infused El Jimador blanco tequila, fresh lime, and agave nectar. Muddled baby tomatoes complete the south of the border-styled sipper. Make a reservation at Double Take.

Mezcal Cocktails for Cinco de Mayo

Summer House Santa Monica, Chicago, Illinois
Rico Suave: Gerardo’s greatest and only hit, and the name of this svelte ‘n’ sexy take on a margarita. Banhez mezcal provides the smoky vibes, while watermelon and lime juice brighten it up. A few drops of Hellfire Bitters add a spike of spice. Make a reservation at Summer House Santa Monica.

Mezcal Cocktails for Cinco de Mayo

DNV Rooftop Lounge, Washington, D.C.
As the name implies, Las Tres Emes features three ingredients starting with the letter m: mezcal, mango nectar, and mole blanco. They’re complemented with tequila, lime, habanero-honey syrup, and chocolate bitters. It all adds up to a cocktail that will make you go, “Mmm.” Make a reservation at DNV Rooftop.

Mezcal Cocktails for Cinco de Mayo

Panzano, Denver, Colorado
The Graffito has double the dose thanks to the use of Ilegal mezcal reposado and Del Maguey Vida mezcal. They’re rounded out with two types of amaro and crème de cassis. The cocktail is served in a rocks glass and garnished with an orange twist. Make a reservation at Panzano.

Mezcal Cocktails for Cinco de Mayo

Viale dei Romani, West Hollywood, California
Oaxacalifornia Love knows how to party. That’s because it’s made with El Silencio mezcal, tequila, lime juice, pineapple, and Fresno chiles. It’ll make you shake, shake it, baby. Make a reservation at Viale dei Romani.

Mezcal Cocktails for Cinco de Mayo

Poca Madre, Washington, D.C.
The flavors in the Kid Dynomite are, well, explosive. (Sorry, we couldn’t help ourselves.). Mezcal is mixed with La Cigarrera Manzanilla, rhubarb, strawberry, lemon, and habanero. Make a reservation at Poca Madre.

Mezcal Cocktails for Cinco de Mayo

Are you celebrating Cinco de Mayo with mezcal cocktails at a restaurant on OpenTable? Let us know where here or over on FacebookInstagramPinterest, or Twitter. And, remember to snap + share your #dishpics with us on Instagram for a chance to win in our weekly giveaway.

Nevin Martell is a Washington, D.C.-based food and travel writer and the author of several books, including Freak Show Without A Tent: Swimming with Piranhas, Getting Stoned in Fiji and Other Family Vacations. Find him on Twitter @nevinmartell and Instagram @nevinmartell.

Photo credits: Raisa Aziz (Doi Moi); Nathaniel Crawford (8UP); Joshua Ferguson (Summer House Santa Monica); Julia Majors (DNV Rooftop); Panzano (Panzano); Greg Powers (Poca Madre).